| Function | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization. Specifically recognizes growing microtubule minus-ends and stabilizes microtubules. Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization. In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation. Through interaction with spectrin may regulate neurite outgrowth. |
| Protein Name | Calmodulin-Regulated Spectrin-Associated Protein 1 |
| Cellular Localisation | CytoplasmCytoskeletonAssociates With The Minus-End Of MicrotubulesIn Contrast To Camsap2 And Camsap3Does Not Form Stretches Of Decorated Microtubule Minus-Ends |
| Alternative Antibody Names | Anti-Calmodulin-Regulated Spectrin-Associated Protein 1 antibodyAnti-CAMSAP1 antibody |
Information sourced from Uniprot.org
