| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CIITA (650-750) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CIITA |
| Gene ID: |
4261 |
| Uniprot ID: |
C2TA_HUMAN |
| Immunogen Region: |
650-750 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 650-750 of human CIITA (NP_000237.2). |
| Immunogen Sequence: |
LDSPPGALAELAKLAWELGR RHQSTLQEDQFPSADVRTWA MAKGLVQHPPRAAESELAFP SFLLQCFLGALWLALSGEIK DKELPQYLALTPRKKRPYDN W |
| Post Translational Modifications | Autophosphorylated, affecting interaction with TAF7. |
| Function | Essential for transcriptional activity of the HLA class II promoter.activation is via the proximal promoter. Does not bind DNA. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both PubMed:8402893, PubMed:7749984,. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription.the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Activates CD74 transcription. Exhibits intrinsic GTP-stimulated acetyltransferase activity. Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro). Has antiviral activity against Ebola virus and coronaviruses, including SARS-CoV-2. Induces resistance by up-regulation of the p41 isoform of CD74, which blocks cathepsin-mediated cleavage of viral glycoproteins, thereby preventing viral fusion. Isoform 3: Exhibits dominant-negative suppression of MHC class II gene expression. |
| Protein Name | Mhc Class Ii TransactivatorCiita |
| Database Links | Reactome: R-HSA-877300 |
| Cellular Localisation | NucleusPml BodyRecruited To Pml Body By Pml |
| Alternative Antibody Names | Anti-Mhc Class Ii Transactivator antibodyAnti-Ciita antibodyAnti-CIITA antibodyAnti-MHC2TA antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
