| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CALM2 |
| Gene ID: | 801/805/808 |
| Uniprot ID: | CALM2_HUMAN |
| Immunogen Region: | 1-149 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-149 of human CALM2 (NP_001734.1). |
| Immunogen Sequence: | MADQLTEEQIAEFKEAFSLF DKDGDGTITTKELGTVMRSL GQNPTEAELQDMINEVDADG NGTIDFPEFLTMMARKMKDT DSEEEIREAFRVFDKDGNGY ISAAELRHVMTNLGEKLTDE EVDEMIREADIDGDGQVNYE EFVQMMTAK |
| Post Translational Modifications | Ubiquitination results in a strongly decreased activity. Phosphorylation results in a decreased activity. |
| Function | Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Calcium-binding is required for the activation of calmodulin. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Mediates calcium-dependent inactivation of CACNA1C. Positively regulates calcium-activated potassium channel activity of KCNN2. (Microbial infection) Required for C.violaceum CopC and S.flexneri OspC3 arginine ADP-riboxanase activity. |
| Protein Name | Calmodulin-2 |
| Database Links | Reactome: R-HSA-111932Reactome: R-HSA-111933Reactome: R-HSA-111957Reactome: R-HSA-111997Reactome: R-HSA-114608Reactome: R-HSA-1445148Reactome: R-HSA-1474151Reactome: R-HSA-163615Reactome: R-HSA-180024Reactome: R-HSA-1855204Reactome: R-HSA-2025928Reactome: R-HSA-203615Reactome: R-HSA-2151201Reactome: R-HSA-2514859Reactome: R-HSA-2672351Reactome: R-HSA-2871809Reactome: R-HSA-4086398Reactome: R-HSA-418359Reactome: R-HSA-425561Reactome: R-HSA-438066Reactome: R-HSA-442720Reactome: R-HSA-442729Reactome: R-HSA-442982Reactome: R-HSA-445355Reactome: R-HSA-451308Reactome: R-HSA-5210891Reactome: R-HSA-5218920Reactome: R-HSA-5218921Reactome: R-HSA-5576892Reactome: R-HSA-5578775Reactome: R-HSA-5607763Reactome: R-HSA-5626467Reactome: R-HSA-5627123Reactome: R-HSA-5673000Reactome: R-HSA-5673001Reactome: R-HSA-6802946Reactome: R-HSA-6802952Reactome: R-HSA-6802955Reactome: R-HSA-70221Reactome: R-HSA-8876725Reactome: R-HSA-9009391Reactome: R-HSA-9022535Reactome: R-HSA-9022692Reactome: R-HSA-936837Reactome: R-HSA-9617324Reactome: R-HSA-9619229Reactome: R-HSA-9619483Reactome: R-HSA-9620244Reactome: R-HSA-9648002Reactome: R-HSA-9649948Reactome: R-HSA-9656223Reactome: R-HSA-9664323Reactome: R-HSA-983695Reactome: R-HSA-9856530 |
| Cellular Localisation | CytoplasmCytoskeletonSpindleSpindle PoleMicrotubule Organizing CenterCentrosomeDistributed Throughout The Cell During InterphaseBut During Mitosis Becomes Dramatically Localized To The Spindle Poles And The Spindle Microtubules |
| Alternative Antibody Names | Anti-Calmodulin-2 antibodyAnti-CALM2 antibodyAnti-CAM2 antibodyAnti-CAMB antibody |
Information sourced from Uniprot.org
