| Function | Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions. In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells. Seems to enhance inorganic pyrophosphatase thus activating phosphogluomutase (PMG). Probably functions as a component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth. |
| Protein Name | Calcium-Binding And Coiled-Coil Domain-Containing Protein 1CalphoglinCoiled-Coil Coactivator ProteinSarcoma Antigen Ny-Sar-3 |
| Cellular Localisation | CytoplasmNucleusShuttles Between Nucleus And Cytoplasm |
| Alternative Antibody Names | Anti-Calcium-Binding And Coiled-Coil Domain-Containing Protein 1 antibodyAnti-Calphoglin antibodyAnti-Coiled-Coil Coactivator Protein antibodyAnti-Sarcoma Antigen Ny-Sar-3 antibodyAnti-CALCOCO1 antibodyAnti-KIAA1536 antibodyAnti-PP13275 antibodyAnti-UNQ2436 antibodyAnti-PRO4996 antibody |
Information sourced from Uniprot.org
