| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CALCOCO1 |
| Gene ID: |
57658 |
| Uniprot ID: |
CACO1_HUMAN |
| Immunogen Region: |
462-691 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 462-691 of human CALCOCO1 (NP_065949.1). |
| Immunogen Sequence: |
LVQLSESKRELTELRSALRV LQKEKEQLQEEKQELLEYMR KLEARLEKVADEKWNEDATT EDEEAAVGLSCPAALTDSED ESPEDMRLPPYGLCERGDPG SSPAGPREASPLVVISQPAP ISPHLSGPAEDSSSDSEAED EKSVLMAAVQSGGEEANLLL PELGSAFYDMASGFTVGTLS ETSTGGPATPTWKECPICKE RFPAESDKDALEDHMDGHFF FSTQDPFTFE |
| Function | Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions. In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells. Seems to enhance inorganic pyrophosphatase thus activating phosphogluomutase (PMG). Probably functions as a component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth. |
| Protein Name | Calcium-Binding And Coiled-Coil Domain-Containing Protein 1CalphoglinCoiled-Coil Coactivator ProteinSarcoma Antigen Ny-Sar-3 |
| Cellular Localisation | CytoplasmNucleusShuttles Between Nucleus And Cytoplasm |
| Alternative Antibody Names | Anti-Calcium-Binding And Coiled-Coil Domain-Containing Protein 1 antibodyAnti-Calphoglin antibodyAnti-Coiled-Coil Coactivator Protein antibodyAnti-Sarcoma Antigen Ny-Sar-3 antibodyAnti-CALCOCO1 antibodyAnti-KIAA1536 antibodyAnti-PP13275 antibodyAnti-UNQ2436 antibodyAnti-PRO4996 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
