| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CALCOCO1 (462-691) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CALCOCO1 |
| Gene ID: |
57658 |
| Uniprot ID: |
CACO1_HUMAN |
| Immunogen Region: |
462-691 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 462-691 of human CALCOCO1 (NP_065949.1). |
| Immunogen Sequence: |
LVQLSESKRELTELRSALRV LQKEKEQLQEEKQELLEYMR KLEARLEKVADEKWNEDATT EDEEAAVGLSCPAALTDSED ESPEDMRLPPYGLCERGDPG SSPAGPREASPLVVISQPAP ISPHLSGPAEDSSSDSEAED EKSVLMAAVQSGGEEANLLL PELGSAFYDMASGFTVGTLS ETSTGGPATPTWKECPICKE RFPAESDKDALEDHMDGHFF FSTQDPFTFE |
| Function | Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions. In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells. Seems to enhance inorganic pyrophosphatase thus activating phosphogluomutase (PMG). Probably functions as component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth. |
| Protein Name | Calcium-Binding And Coiled-Coil Domain-Containing Protein 1CalphoglinCoiled-Coil Coactivator ProteinSarcoma Antigen Ny-Sar-3 |
| Cellular Localisation | CytoplasmNucleusShuttles Between Nucleus And Cytoplasm |
| Alternative Antibody Names | Anti-Calcium-Binding And Coiled-Coil Domain-Containing Protein 1 antibodyAnti-Calphoglin antibodyAnti-Coiled-Coil Coactivator Protein antibodyAnti-Sarcoma Antigen Ny-Sar-3 antibodyAnti-CALCOCO1 antibodyAnti-KIAA1536 antibodyAnti-PP13275 antibodyAnti-UNQ2436 antibodyAnti-PRO4996 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
