• Human thyroid medullary carcinoma stained with anti-Calcitonin antibody using peroxidase-conjugate and DAB. Note cytoplasmic staining of tumor cells.

Anti-Calcitonin antibody (3-116aa) [ZM301] (STJ180552)

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STJ180552

£163.50 - £634.50
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Host: Mouse
Applications: IHC-P
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Calcitonin (3-116aa) is suitable for use in Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: ZM301
Conjugation: Unconjugated
Isotype: IgG2b/Kappa
Formulation: Tris-HCI buffer containing stabilizing protein (BSA) and <0.1% ProClin
Purification: Affinity purified
Dilution Range: 1:100-200
Storage Instruction: Store at 2‐8°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate lab‐standardized diluent. Stability after dilution: 7 days at 24°C, 3 months at 2‐8°C, 6months at ‐20°C.
Immunogen Region: 3-116aa
Specificity: Positive Control: Thyroid or medullary carcinoma
Immunogen: Recombinant fragment of human Calcitonin protein (around aa 3-116)
Background Calcitonin is a 32 amino acid polypeptide hormone that preserves skeletal integrity and reduces blood calcium levels by decreasing osteoclast activity in bones, calcium and phosphate reabsorption by kidney tubules, and calcium absorption by the intestines. The secretion of Calcitonin from the thyroid is regulated in part by estrogen, which increases Calcitonin mRNA levels. The Calcitonin gene, CALCA, undergoes tissue-specific RNA alternative splicing, resulting in the production of different mRNA transcripts. One transcript encodes procalcitonin and both calcium-lowering processed active polypeptides, Calcitonin, and katacalcin. An alternative transcript of CALCA encodes the precursor for the neuropeptide called Calcitonin gene-related peptide 1, also designated CGRP1 or-CGRP. CGRP is a widely distributed vasodilatory peptide. Calcitonin and katacalcin are produced primarily in the thyroid, while CGRP is produced in neuronal cells. A second CGRP related gene, CALCB, which is thought to be derived from a gene duplication event, has been identified in mice, rats, and humans. Unlike CALCA, CALCB is not subject to alternative splicing and encodes a single transcript designated CGRP2 or-CGRP. Mature CGRP1 and CGRP2 share significant sequence identity at the protein level differing by only 1-3 amino acid residues, depending on the species.

Information sourced from Uniprot.org

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