| Host: | Rabbit |
| Applications: | IHC-P/ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CALCA |
| Gene ID: | 796 |
| Uniprot ID: | CALCA_HUMAN |
| Immunogen Region: | 26-128 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-128 of CALCA (NP_001029125.1). |
| Immunogen Sequence: | APFRSALESSPADPATLSED EARLLLAALVQDYVQMKASE LEQEQEREGSRIIAQKRACD TATCVTHRLAGLLSRSGGVV KNNFVPTNVGSKAFGRRRRD LQA |
| Tissue Specificity | Expressed in spinal cord. |
| Function | CGRP1/CALCA is a peptide hormone that induces vasodilation mediated by the CALCRL-RAMP1 receptor complex. Dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP. CGRP1 can also bind and activate CALCR-RAMP1 (AMYR1) receptor complex. |
| Protein Name | Calcitonin Gene-Related Peptide 1Cgrp1Alpha-Type CgrpCalcitonin Gene-Related Peptide ICgrp-I |
| Database Links | Reactome: R-HSA-418555Reactome: R-HSA-419812Reactome: R-HSA-977225 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Calcitonin Gene-Related Peptide 1 antibodyAnti-Cgrp1 antibodyAnti-Alpha-Type Cgrp antibodyAnti-Calcitonin Gene-Related Peptide I antibodyAnti-Cgrp-I antibodyAnti-CALCA antibodyAnti-CALC1 antibody |
Information sourced from Uniprot.org