Anti-CADPS antibody (1275-1325 aa) (STJ194357)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human CAPS1 at the amino acid range 1275-1325
General Information
| Short Description | Rabbit polyclonal anti-Calcium-dependent secretion activator 1 (1275-1325 aa) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CADPS |
| Gene ID | 8618 |
| Uniprot ID | CAPS1_HUMAN |
| Immunogen | Synthesized peptide derived from the human CAPS1 at the amino acid range 1275-1325 |
| Immunogen Region | 1275-1325 aa |
| Specificity | This antibody detects endogenous levels of CAPS1 at Human/Mouse/Rat |
Additional Info
| Function | Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering. |
| Protein Name | Calcium-Dependent Secretion Activator 1Calcium-Dependent Activator Protein For Secretion 1Caps-1 |
| Database Links | |
| Cellular Localisation | SynapseCytoplasmic VesicleSecretory VesicleNeuronal Dense Core Vesicle MembranePeripheral Membrane ProteinMembrane-Associated To VesiclesStrongly Enriched In Synaptic FractionsPreferentially Binds To Dense Core Vesicles But Not To Synaptic VesiclesBinds PhosphoinosidesWith A Strong Selectivity For Ptdins(45)P2 Over Ptdins(345)P3Probably Localizes To Different Vesicles Compared To Cadps2 |
| Alternative Antibody Names | Anti-Calcium-Dependent Secretion Activator 1 antibodyAnti-Calcium-Dependent Activator Protein For Secretion 1 antibodyAnti-Caps-1 antibodyAnti-CADPS antibodyAnti-CAPS antibodyAnti-CAPS1 antibodyAnti-KIAA1121 antibody |
Information sourced from Uniprot.org