| Function | Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering. |
| Protein Name | Calcium-Dependent Secretion Activator 1Calcium-Dependent Activator Protein For Secretion 1Caps-1 |
| Cellular Localisation | SynapseCytoplasmic VesicleSecretory VesicleNeuronal Dense Core Vesicle MembranePeripheral Membrane ProteinMembrane-Associated To VesiclesStrongly Enriched In Synaptic FractionsPreferentially Binds To Dense Core Vesicles But Not To Synaptic VesiclesBinds PhosphoinosidesWith A Strong Selectivity For Ptdins(45)P2 Over Ptdins(345)P3Probably Localizes To Different Vesicles Compared To Cadps2 |
| Alternative Antibody Names | Anti-Calcium-Dependent Secretion Activator 1 antibodyAnti-Calcium-Dependent Activator Protein For Secretion 1 antibodyAnti-Caps-1 antibodyAnti-CADPS antibodyAnti-CAPS antibodyAnti-CAPS1 antibodyAnti-KIAA1121 antibody |
Information sourced from Uniprot.org
