| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Voltage-dependent calcium channel gamma-8 subunit (140-220 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CACNG8 |
| Gene ID: | 59283 |
| Uniprot ID: | CCG8_HUMAN |
| Immunogen Region: | 140-220 aa |
| Specificity: | CCG8 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from the human protein at the amino acid range 140-220 |
| Post Translational Modifications | Palmitoylated. Probably palmitoylated by ZDHHC3 and ZDHHC7. |
| Function | Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. |
| Protein Name | Voltage-Dependent Calcium Channel Gamma-8 Subunit Neuronal Voltage-Gated Calcium Channel Gamma-8 Subunit Transmembrane Ampar Regulatory Protein Gamma-8 Tarp Gamma-8 |
| Database Links | Reactome: R-HSA-399719 Reactome: R-HSA-5576892 Reactome: R-HSA-5576893 Reactome: R-HSA-5682910 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Postsynaptic Density Membrane |
| Alternative Antibody Names | Anti-Voltage-Dependent Calcium Channel Gamma-8 Subunit antibody Anti-Neuronal Voltage-Gated Calcium Channel Gamma-8 Subunit antibody Anti-Transmembrane Ampar Regulatory Protein Gamma-8 antibody Anti-Tarp Gamma-8 antibody Anti-CACNG8 antibody Anti-CACNG6 antibody |
Information sourced from Uniprot.org