| Post Translational Modifications | The alpha-1S subunit is found in two isoforms in the skeletal muscle: a minor form of 212 kDa containing the complete amino acid sequence, and a major form of 190 kDa derived from the full-length form by post-translational proteolysis close to Phe-1690. Phosphorylated. Phosphorylation by PKA activates the calcium channel. Both the minor and major forms are phosphorylated in vitro by PKA. Phosphorylation at Ser-1575 is involved in beta-adrenergic-mediated regulation of the channel. |
| Function | Pore-forming, alpha-1S subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle via their interaction with RYR1, which triggers Ca(2+) release from the sarcoplasmic reticulum and ultimately results in muscle contraction. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. |
| Protein Name | Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1sCalcium Channel - L Type - Alpha-1 Polypeptide - Isoform 3 - Skeletal MuscleVoltage-Gated Calcium Channel Subunit Alpha Cav1.1 |
| Database Links | Reactome: R-HSA-419037 |
| Cellular Localisation | Cell MembraneSarcolemmaT-TubuleMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1s antibodyAnti-Calcium Channel - L Type - Alpha-1 Polypeptide - Isoform 3 - Skeletal Muscle antibodyAnti-Voltage-Gated Calcium Channel Subunit Alpha Cav1.1 antibodyAnti-CACNA1S antibodyAnti-CACH1 antibodyAnti-CACN1 antibodyAnti-CACNL1A3 antibody |
Information sourced from Uniprot.org
