Anti-CACNA1H antibody (2000-2050 aa) (STJ13100954)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from aa region 2000-2050 of human CACNA1H conjugated to blue carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-CACNA1H (2000-2050 aa) for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | CACNA1H |
| Gene ID | 8912 |
| Uniprot ID | CAC1H_HUMAN |
| Immunogen | A synthetic peptide from aa region 2000-2050 of human CACNA1H conjugated to blue carrier protein was used as the antigen. |
| Immunogen Region | 2000-2050 aa |
| Specificity | Specific for CACNA1H. |
Additional Info
| Post Translational Modifications | In response to raising of intracellular calcium, the T-type channels are activated by CaM-kinase II. |
| Function | Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle (Probable). They may also be involved in the modulation of firing patterns of neurons. In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia. |
| Protein Name | Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1hLow-Voltage-Activated Calcium Channel Alpha1 3.2 SubunitVoltage-Gated Calcium Channel Subunit Alpha Cav3.2 |
| Database Links | Reactome: R-HSA-419037Reactome: R-HSA-445355Reactome: R-HSA-9856532 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinInteraction With Stac Increases Expression At The Cell Membrane |
| Alternative Antibody Names | Anti-Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1h antibodyAnti-Low-Voltage-Activated Calcium Channel Alpha1 3.2 Subunit antibodyAnti-Voltage-Gated Calcium Channel Subunit Alpha Cav3.2 antibodyAnti-CACNA1H antibody |
Information sourced from Uniprot.org