Anti-CACNA1H antibody (1718-1768 aa) (STJ197414)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide derived from Cav3.2 at the amino acid range 1718-1768
General Information
| Short Description | Rabbit polyclonal anti-Voltage-dependent T-type calcium channel subunit alpha-1H (1718-1768 aa) for use in IHC and IF in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC 1:50-100IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CACNA1H |
| Gene ID | 8912 |
| Uniprot ID | CAC1H_HUMAN |
| Immunogen | Synthetic peptide derived from Cav3.2 at the amino acid range 1718-1768 |
| Immunogen Region | 1718-1768 aa |
| Specificity | Cav3.2 protein (A208) detects endogenous levels of Cav3.2 |
Additional Info
| Post Translational Modifications | In response to raising of intracellular calcium, the T-type channels are activated by CaM-kinase II. |
| Function | Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle (Probable). They may also be involved in the modulation of firing patterns of neurons. In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia. |
| Protein Name | Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1hLow-Voltage-Activated Calcium Channel Alpha1 3.2 SubunitVoltage-Gated Calcium Channel Subunit Alpha Cav3.2 |
| Database Links | Reactome: R-HSA-419037Reactome: R-HSA-445355Reactome: R-HSA-9856532 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinInteraction With Stac Increases Expression At The Cell Membrane |
| Alternative Antibody Names | Anti-Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1h antibodyAnti-Low-Voltage-Activated Calcium Channel Alpha1 3.2 Subunit antibodyAnti-Voltage-Gated Calcium Channel Subunit Alpha Cav3.2 antibodyAnti-CACNA1H antibody |
Information sourced from Uniprot.org