Anti-CACNA1G antibody (360-440 aa) (STJ191633)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 360-440
General Information
| Short Description | Rabbit polyclonal anti-Voltage-dependent T-type calcium channel subunit alpha-1G (360-440 aa) for use in IHC and IF in Human and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC-P 1:50-300IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CACNA1G |
| Gene ID | 8913 |
| Uniprot ID | CAC1G_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 360-440 |
| Immunogen Region | 360-440 aa |
| Specificity | CAC1G Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | In response to raising of intracellular calcium, the T-type channels are activated by CaM-kinase II. |
| Function | Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group and are strongly blocked by mibefradil. A particularity of this type of channel is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Isoform 2: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. |
| Protein Name | Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1gCav3.1cNbr13Voltage-Gated Calcium Channel Subunit Alpha Cav3.1 |
| Database Links | Reactome: R-HSA-419037Reactome: R-HSA-445355 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCytoplasm |
| Alternative Antibody Names | Anti-Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1g antibodyAnti-Cav3.1c antibodyAnti-Nbr13 antibodyAnti-Voltage-Gated Calcium Channel Subunit Alpha Cav3.1 antibodyAnti-CACNA1G antibodyAnti-KIAA1123 antibody |
Information sourced from Uniprot.org