Anti-CACNA1D antibody (1882-2181) (STJ11102779)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CACNA1D (1882-2181) antibody for use in WB and ELISA in human and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CACNA1D |
| Gene ID | 776 |
| Uniprot ID | CAC1D_HUMAN |
| Immunogen Region | 1882-2181 |
| Immunogen Sequence | RQNYGYYSRYPGRNIDSERP RGYHHPQGFLEDDDSPVCYD SRRSPRRRLLPPTPASHRRS SFNFECLRRQSSQEEVPSSP IFPHRTALPLHLMQQQIMAV AGLDSSKAQKYSPSHSTRSW ATPPATPPYRDWTPCYTPLI QVEQSEALDQVNGSLPSLHR SSWYTDEPDISYRTFTPASL TVPSSFRNKNSDKQRSADSL VEAVLISEGLGRYARDPKFV SATKHEIADACDLTIDEME |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1882-2181 of human CACNA1D (NP_000711.1). |
Additional Info
| Tissue Specificity | Expressed in pancreatic islets and in brain, where it has been seen in cerebral cortex, hippocampus, basal ganglia, habenula and thalamus. Expressed in the small cell lung carcinoma cell line SCC-9. No expression in skeletal muscle. |
| Function | Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines. Isoform Neuronal-type: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Isoform 3: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Isoform 4: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. |
| Protein Name | Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1dCalcium Channel - L Type - Alpha-1 Polypeptide - Isoform 2Voltage-Gated Calcium Channel Subunit Alpha Cav1.3 |
| Database Links | Reactome: R-HSA-400042Reactome: R-HSA-419037Reactome: R-HSA-422356Reactome: R-HSA-9662360 |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1d antibodyAnti-Calcium Channel - L Type - Alpha-1 Polypeptide - Isoform 2 antibodyAnti-Voltage-Gated Calcium Channel Subunit Alpha Cav1.3 antibodyAnti-CACNA1D antibodyAnti-CACH3 antibodyAnti-CACN4 antibodyAnti-CACNL1A2 antibodyAnti-CCHL1A2 antibody |
Information sourced from Uniprot.org