Anti-CACNA1C antibody (2035-2135 aa) (STJ13100952)

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STJ13100952-100
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Host: Rabbit
Applications: IHC/WB
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-CACNA1C (2035-2135 aa) is suitable for use in Immunohistochemistry and Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Lyophilised
Purification: IgG purified
Dilution Range: IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not tested in other applications.
Storage Instruction: Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Gene Symbol: Cacna1c
Gene ID: 12288
Uniprot ID: CAC1C_MOUSE
Immunogen Region: 2035-2135 aa
Specificity: Specific for CACNA1C.
Immunogen: A synthetic peptide from aa region 2035-2135 of mouse CACNA1C (Cav1.2) conjugated to an immunogenic carrier protein was used as the antigen.
Post Translational Modifications Phosphorylation by PKA at Ser-1897 activates the channel. Elevated levels of blood glucose lead to increased phosphorylation by PKA.
Function Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable).
Protein Name Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1c
Calcium Channel - L Type - Alpha-1 Polypeptide - Isoform 1 - Cardiac Muscle
Melc-Cc
Mouse Brain Class C
Mbc
Voltage-Gated Calcium Channel Subunit Alpha Cav1.2
Database Links Reactome: R-MMU-422356
Reactome: -MMU-5576892
Reactome: -MMU-5576893
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Sarcolemma
Perikaryon
Postsynaptic Density Membrane
Cell Projection
Dendrite
T-Tubule
Colocalizes With Ryanodine Receptors In Distinct Clusters At The Junctional Membrane
Where The Sarcolemma And The Sarcoplasmic Reticulum Are In Close Contact
The Interaction Between Rrad And Cacnb2 Promotes The Expression Of Cacna1c At The Cell Membrane
Localized In T-Tubules
As Shown In Serca2-Knockout Cardiomyocytes
Alternative Antibody Names Anti-Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1c antibody
Anti-Calcium Channel - L Type - Alpha-1 Polypeptide - Isoform 1 - Cardiac Muscle antibody
Anti-Melc-Cc antibody
Anti-Mouse Brain Class C antibody
Anti-Mbc antibody
Anti-Voltage-Gated Calcium Channel Subunit Alpha Cav1.2 antibody
Anti-Cacna1c antibody
Anti-Cach2 antibody
Anti-Cacn2 antibody
Anti-Cacnl1a1 antibody
Anti-Cchl1a1 antibody

Information sourced from Uniprot.org

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