| Tissue Specificity | Detected throughout the brain, including hippocampus, cerebellum and amygdala, throughout the heart and vascular system, including ductus arteriosus, in urinary bladder, and in retina and sclera in the eye. Expressed in brain, heart, jejunum, ovary, pancreatic beta-cells and vascular smooth muscle. Overall expression is reduced in atherosclerotic vascular smooth muscle. |
| Post Translational Modifications | Phosphorylation by PKA at Ser-1981 activates the channel. Elevated levels of blood glucose lead to increased phosphorylation by PKA. |
| Function | Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable). Isoform 12: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Isoform 13: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Isoform 14: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Isoform 15: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Isoform 16: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Isoform 17: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Isoform 18: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Isoform 19: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Isoform 20: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Isoform 21: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Isoform 22: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Isoform 23: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Isoform 24: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Isoform 25: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Isoform 26: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Isoform 27: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Isoform 34: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. (Microbial infection) Acts as a receptor for Influenzavirus. May play a critical role in allowing virus entry when sialylated and expressed on lung tissues. |
| Protein Name | Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1cCalcium Channel - L Type - Alpha-1 Polypeptide - Isoform 1 - Cardiac MuscleVoltage-Gated Calcium Channel Subunit Alpha Cav1.2 |
| Database Links | Reactome: R-HSA-400042Reactome: R-HSA-419037Reactome: R-HSA-422356Reactome: R-HSA-5576892Reactome: R-HSA-5576893 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinSarcolemmaPerikaryonPostsynaptic Density MembraneCell ProjectionDendriteT-TubuleColocalizes With Ryanodine Receptors In Distinct Clusters At The Junctional MembraneWhere The Sarcolemma And The Sarcoplasmic Reticulum Are In Close ContactThe Interaction Between Rrad And Cacnb2 Promotes The Expression Of Cacna1c At The Cell Membrane |
| Alternative Antibody Names | Anti-Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1c antibodyAnti-Calcium Channel - L Type - Alpha-1 Polypeptide - Isoform 1 - Cardiac Muscle antibodyAnti-Voltage-Gated Calcium Channel Subunit Alpha Cav1.2 antibodyAnti-CACNA1C antibodyAnti-CACH2 antibodyAnti-CACN2 antibodyAnti-CACNL1A1 antibodyAnti-CCHL1A1 antibody |
Information sourced from Uniprot.org
