Anti-CABIN1 antibody (STJ190620)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Calcineurin-binding protein cabin-1 for use in WB and ELISA in Human and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CABIN1 |
| Gene ID | 23523 |
| Uniprot ID | CABIN_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | CABIN Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Activated through PKC-mediated hyperphosphorylation. Phosphorylation by the DNA damage kinases ATM and CHK2 enhances ubiquitination. Upon genotoxic stress, ubiquitination by the DCX(DDB2) E3 ubiquitin-protein ligase complex targets CABIN1 for proteasomal degradation, leading to the release of p53/TP53. |
| Function | May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes. |
| Protein Name | Calcineurin-Binding Protein Cabin-1Calcineurin InhibitorCain |
| Database Links | Reactome: R-HSA-2559584 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Calcineurin-Binding Protein Cabin-1 antibodyAnti-Calcineurin Inhibitor antibodyAnti-Cain antibodyAnti-CABIN1 antibodyAnti-KIAA0330 antibody |
Information sourced from Uniprot.org