| Post Translational Modifications | Activated through PKC-mediated hyperphosphorylation. Phosphorylation by the DNA damage kinases ATM and CHK2 enhances ubiquitination. Upon genotoxic stress, ubiquitination by the DCX(DDB2) E3 ubiquitin-protein ligase complex targets CABIN1 for proteasomal degradation, leading to the release of p53/TP53. |
| Function | May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes. |
| Protein Name | Calcineurin-Binding Protein Cabin-1Calcineurin InhibitorCain |
| Database Links | Reactome: R-HSA-2559584 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Calcineurin-Binding Protein Cabin-1 antibodyAnti-Calcineurin Inhibitor antibodyAnti-Cain antibodyAnti-CABIN1 antibodyAnti-KIAA0330 antibody |
Information sourced from Uniprot.org
