| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | C7orf50 |
| Gene ID: | 84310 |
| Uniprot ID: | CHOLN_HUMAN |
| Immunogen Region: | 1-194 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-194 of human C7orf50 (NP_115726.1). |
| Immunogen Sequence: | MAKQKRKVPEVTEKKNKKLK KASAEGPLLGPEAAPSGEGA GSKGEAVLRPGLDAEPELSP EEQRVLERKLKKERKKEERQ RLREAGLVAQHPPARRSGAE LALDYLCRWAQKHKNWRFQK TRQTWLLLHMYDSDKVPDEH FSTLLAYLEGLQGRARELTV QKAEALMRELDEEGSDPPLP GRAQRIRQVLQLLS |
| Tissue Specificity | Secreted from the instestine, secretion is induced by feeding and cholesterol absorption. |
| Function | Hormone secreted from the intestine in response to cholesterol, where it acts to inhibit cholesterol synthesis in the liver and VLDL secretion,leading to a reduction in circulating cholesterol levels. Acts through binding to its receptor, GPR146. |
| Protein Name | Protein Cholesin |
| Cellular Localisation | SecretedSecreted Via ExosomesSecretion Is Induced By Feeding And Cholesterol Absorption |
| Alternative Antibody Names | Anti-Protein Cholesin antibodyAnti-C7orf50 antibodyAnti-FP15621 antibody |
Information sourced from Uniprot.org