| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | C7 |
| Gene ID: | 730 |
| Uniprot ID: | CO7_HUMAN |
| Immunogen Region: | 22-270 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 22-270 of human C7 (NP_000578.2). |
| Immunogen Sequence: | ASSPVNCQWDFYAPWSECNG CTKTQTRRRSVAVYGQYGGQ PCVGNAFETQSCEPTRGCPT EEGCGERFRCFSGQCISKSL VCNGDSDCDEDSADEDRCED SERRPSCDIDKPPPNIELTG NGYNELTGQFRNRVINTKSF GGQCRKVFSGDGKDFYRLSG NVLSYTFQVKINNDFNYEFY NSTWSYVKHTSTEHTSSSRK RSFFRSSSSSSRSYTSHTNE IHKGKSYQLLVVENTVEVA |
| Post Translational Modifications | C7 has 28 disulfide bridges. C-, N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. |
| Function | Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor. |
| Protein Name | Complement Component C7 |
| Database Links | Reactome: R-HSA-166665Reactome: R-HSA-977606 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Complement Component C7 antibodyAnti-C7 antibody |
Information sourced from Uniprot.org