| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | C4BPB |
| Gene ID: | 725 |
| Uniprot ID: | C4BPB_HUMAN |
| Immunogen Region: | 17-251 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 17-251 of human C4BPB (NP_001017364.1). |
| Immunogen Sequence: | ASDEHCPELPPVDNSIFVAK EVEGQILGTYVCIKGYHLVG KKTLFCNASKEWDNTTTECR LGHCPDPVLVNGEFSSSGPV NVSDKITFMCNDHYILKGSN RSQCLEDHTWAPPFPICKSR DCDPPGNPVHGYFEGNNFTL GSTISYYCEDRYYLVGVQEQ QCVDGEWSSALPVCKLIQEA PKPECEKALLAFQESKNLCE AMENFMQQLKESGMTMEELK YSLELKKAELKAKLL |
| Function | Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S. |
| Protein Name | C4b-Binding Protein Beta Chain |
| Database Links | Reactome: R-HSA-977606 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-C4b-Binding Protein Beta Chain antibodyAnti-C4BPB antibody |
Information sourced from Uniprot.org