| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | C2CD5 |
| Gene ID: | 9847 |
| Uniprot ID: | C2CD5_HUMAN |
| Immunogen Region: | 732-1051 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 732-1051 of human C2CD5 (NP_001273103.1). |
| Immunogen Sequence: | RLSSLNLTNQALNKNFNDLC ENLLKSLYFKLRSMIPCCLC HVNFTVSLPEDELIQVTVTA VAITFDKNQALQTTKTPVEK SLQRASTDNEELLQFPLELC SDSLPSHPFPPAKEHLESAS SNSGIPAAQRATSVDYSSFA DRCSSWIELIKLKAQTIRRG SIKTTMTVEKASPVGDGNFR NRSAPPCANSTVGVVKMTPL SFIPGAKITKYLGIINMFFI RETTSLREEGGVSGFLHAF |
| Post Translational Modifications | Phosphorylated on Ser-197 by active myristoylated kinase AKT2.insulin-stimulated phosphorylation by AKT2 regulates SLC2A4/GLUT4 translocation into the plasma membrane. |
| Function | Required for insulin-stimulated glucose transport and glucose transporter SLC2A4/GLUT4 translocation from intracellular glucose storage vesicle (GSV) to the plasma membrane (PM) in adipocytes. Binds phospholipid membranes in a calcium-dependent manner and is necessary for the optimal membrane fusion between SLC2A4/GLUT4 GSV and the PM. |
| Protein Name | C2 Domain-Containing Protein 5C2 Domain-Containing Phosphoprotein Of 138 Kda |
| Database Links | Reactome: R-HSA-1445148 |
| Cellular Localisation | Cytoplasmic Vesicle MembraneCytoplasmCell CortexCell MembraneCell ProjectionRuffleDynamically Associated With Glut4-Containing Glucose Storage Vesicles (Gsv) And Plasma Membrane In Response To Insulin Stimulation |
| Alternative Antibody Names | Anti-C2 Domain-Containing Protein 5 antibodyAnti-C2 Domain-Containing Phosphoprotein Of 138 Kda antibodyAnti-C2CD5 antibodyAnti-CDP138 antibodyAnti-KIAA0528 antibody |
Information sourced from Uniprot.org
