| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-C1QB (104-253) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
C1QB |
| Gene ID: |
713 |
| Uniprot ID: |
C1QB_HUMAN |
| Immunogen Region: |
104-253 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 104-253 of human C1QB (NP_000482.3). |
| Immunogen Sequence: |
PGAPGPKGESGDYKATQKIA FSATRTINVPLRRDQTIRFD HVITNMNNNYEPRSGKFTCK VPGLYYFTYHASSRGNLCVN LMRGRERAQKVVTFCDYAYN TFQVTTGGMVLKLEQGENVF LQATDKNSLLGMEGANSIFS GFLLFPDMEA |
| Post Translational Modifications | Hydroxylated on lysine and proline residues. Hydroxylated lysine residues can be glycosylated. Human C1Q contains up to 68.3 hydroxylysine-galactosylglucose residues and up to 2.5 hydroxylysine-galactose per molecule. Total percentage hydroxylysine residues glycosylated is 86.4%. |
| Function | C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. |
| Protein Name | Complement C1q Subcomponent Subunit B |
| Database Links | Reactome: R-HSA-166663Reactome: R-HSA-173623Reactome: R-HSA-977606 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Complement C1q Subcomponent Subunit B antibodyAnti-C1QB antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
