| Post Translational Modifications | Phosphorylation at Ser-43 by PLK1 strengthens FIRRM-PLK1 interaction. Phosphorylation at Ser-744 by PLK1 negatively regulates its interaction with PPP1CC. |
| Function | Regulates PLK1 kinase activity at kinetochores and promotes faithful chromosome segregation in prometaphase by bridging kinase and phosphatase activities. Phosphorylation of FIRRM by PLK1 negatively regulates its interaction with the phosphatase, PPP1CC, thus creating a negative feedback loop for maintaining proper PLK1 kinase activity during mitosis. In complex with FIGL1 may regulate homologous recombination. |
| Protein Name | Fignl1-Interacting Regulator Of Recombination And MitosisFidgetin-Like-1 Interacting ProteinFlipPolo1-Associating Protein |
| Database Links | Reactome: R-HSA-2500257Reactome: R-HSA-5693568Reactome: R-HSA-912446 |
| Cellular Localisation | ChromosomeCentromereKinetochoreNucleusMidbodyCytoplasmCytoskeletonSpindleExhibits Cell-Cycle-Dependent Distribution During MitosisDetected In The Nucleus In InterphaseColocalizes With Plk1 To The Centromeres In A Nearby Prometaphase CellsRelocates To The Central Spindle In Anaphase And To The Midbody In Telophase Cells |
| Alternative Antibody Names | Anti-Fignl1-Interacting Regulator Of Recombination And Mitosis antibodyAnti-Fidgetin-Like-1 Interacting Protein antibodyAnti-Flip antibodyAnti-Polo1-Associating Protein antibodyAnti-FIRRM antibodyAnti-APOLO1 antibodyAnti-C1orf112 antibody |
Information sourced from Uniprot.org
