Anti-C1orf106 antibody (STJA0004446)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenFusion protein of human C1orf106
General Information
| Short Description | Rabbit polyclonal anti-Innate Immunity Activator Protein for use in IHC and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.9 mg/mL |
| Purification | Antigen affinity purification |
| Dilution Range | IHC 1:50-1:300 |
| Formulation | PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | INAVA |
| Gene ID | 55765 |
| Uniprot ID | INAVA_HUMAN |
| Immunogen | Fusion protein of human C1orf106 |
Additional Info
| Tissue Specificity | Highly expressed in intestinal myeloid-derived cells and expressed in monocyte-derived macrophages upon induction by PRR activation. |
| Function | Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion. In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation. |
| Protein Name | Innate Immunity Activator Protein |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmTranslocates To The Nucleus Upon Nod2 Stimulation |
| Alternative Antibody Names | Anti-Innate Immunity Activator Protein antibodyAnti-INAVA antibodyAnti-C1orf106 antibody |
Information sourced from Uniprot.org