| Tissue Specificity | Specifically expressed in germline tissues. |
| Function | Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. |
| Protein Name | Telomere Repeats-Binding Bouquet Formation Protein 2 |
| Cellular Localisation | ChromosomeTelomereNucleus Inner MembraneLocalizes To Telomeres Throughout Meiotic Prophase I And Disappears In Metaphase IIn Leptotene SpermatocytesLocalizes To Telomeres That Localize To The Nucleus Inner Membrane |
| Alternative Antibody Names | Anti-Telomere Repeats-Binding Bouquet Formation Protein 2 antibodyAnti-Terb2 antibody |
Information sourced from Uniprot.org
