| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | Terb2 |
| Gene ID: | 74401 |
| Uniprot ID: | TERB2_MOUSE |
| Immunogen Region: | 1-218 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-218 of mouse C15orf43 (NP_083190.1). |
| Immunogen Sequence: | MFQGQRGWFCGSVSQDLRQI WEDEGGMVSDVKAADFLFSC DASHPDTLRIYQSLEYIEDN ATVFHAYYLAAIANTEMKNS VALGHFVLPPACLQKEIRRK IGSFIWEQDEKFQIEKHDRM ASSDKENIRPTPEHKQELSK SAEHHLTRTPVIEKQMCFPL HSYPVNNMVTGYISIDALEK FLGELHDFTPGSSGYLAYHI QDEINMSAIKNKLRRKLS |
| Tissue Specificity | Specifically expressed in germline tissues. |
| Function | Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. |
| Protein Name | Telomere Repeats-Binding Bouquet Formation Protein 2 |
| Cellular Localisation | Chromosome Telomere Nucleus Inner Membrane Localizes To Telomeres Throughout Meiotic Prophase I And Disappears In Metaphase I In Leptotene Spermatocytes Localizes To Telomeres That Localize To The Nucleus Inner Membrane |
| Alternative Antibody Names | Anti-Telomere Repeats-Binding Bouquet Formation Protein 2 antibody Anti-Terb2 antibody |
Information sourced from Uniprot.org