Anti-C14orf68 antibody (242-254) (STJ71088)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-C14orf68 (242-254) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/IHC |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Preliminary experiments gave an approx 22kDa band in Human Liver lysates after 0.5ยตg/ml antibody staining. Please note that currently we cannot find an explanation in the literature fo |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20ยฐC on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | SLC25A47 |
| Gene ID | 283600 |
| Uniprot ID | S2547_HUMAN |
| Accession Number | NP_997000.2 |
| Immunogen Region | 242-254 |
| Immunogen Sequence | KSRLQADGQGQRR |
Additional Info
| Function | Mitochondrial NAD(+) transporter that acts as a 'metabolic gate' in hepatic lipogenesis. Provides NAD(+) substrate to mitochondrial SIRT3 deacetylase and enables its NAD(+)-dependent activities in mitochondrial energy metabolism. This triggers downstream activation of PRKAA1/AMPK-alpha signaling cascade that negatively regulates sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance. May transport other mitochondrial metabolites having an aromatic nucleotide and phosphate groups, such as acetyl-CoA. Does not transport amino acids. The transport mechanism remains to be elucidated. |
| Protein Name | Solute Carrier Family 25 Member 47Hepatocellular Carcinoma Down-Regulated Mitochondrial Carrier ProteinMitochondrial Nad(+ Transporter Slc25a47 |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane ProteinMitochondrion Outer Membrane |
| Alternative Antibody Names | Anti-Solute Carrier Family 25 Member 47 antibodyAnti-Hepatocellular Carcinoma Down-Regulated Mitochondrial Carrier Protein antibodyAnti-Mitochondrial Nad(+ Transporter Slc25a47 antibodyAnti-SLC25A47 antibodyAnti-C14orf68 antibodyAnti-HDMCP antibodyAnti-HMFN1655 antibody |
Information sourced from Uniprot.org