| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-BTLA (31-241) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
BTLA |
| Gene ID: |
151888 |
| Uniprot ID: |
BTLA_HUMAN |
| Immunogen Region: |
31-241 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 31-241 of human BTLA (NP_001078826.1). |
| Immunogen Sequence: |
KESCDVQLYIKRQSEHSILA GDPFELECPVKYCANRPHVT WCKLNGTTCVKLEDRQTSWK EEKNISFFILHFEPVLPNDN GSYRCSANFQSNLIESHSTT LYVTGKQNELSDTAGREINL VDAHLKSEQTEASTRQNSQV LLSETGIYDNDPDLCFRMQE GSEVYSNPCLEENKPGIVYA SLNHSVIGPNSRLARNVKEA PTEYASICVRS |
| Post Translational Modifications | Phosphorylated on Tyr residues by TNFRSF14 and by antigen receptors cross-linking, both inducing association with PTPN6 and PTPN11. N-glycosylated. |
| Function | Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells. |
| Protein Name | B- And T-Lymphocyte AttenuatorB- And T-Lymphocyte-Associated ProteinCd Antigen Cd272 |
| Database Links | Reactome: R-HSA-388841 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-B- And T-Lymphocyte Attenuator antibodyAnti-B- And T-Lymphocyte-Associated Protein antibodyAnti-Cd Antigen Cd272 antibodyAnti-BTLA antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
