| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | BTG2 |
| Gene ID: | 7832 |
| Uniprot ID: | BTG2_HUMAN |
| Immunogen Region: | 1-158 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-158 of human BTG2/PC3 (NP_006754.1). |
| Immunogen Sequence: | MSHGKGTDMLPEIAAAVGFL SSLLRTRGCVSEQRLKVFSG ALQEALTEHYKHHWFPEKPS KGSGYRCIRINHKMDPIISR VASQIGLSQPQLHQLLPSEL TLWVDPYEVSYRIGEDGSIC VLYEEAPLAASCGLLTCKNQ VLLGRSSPSKNYVMAVSS |
| Post Translational Modifications | Phosphorylated at Ser-147 by MAPK1/ERK2 and MAPK3/ERK1, and at Ser-149 by MAPK14, leading to PIN1-binding and mitochondrial depolarization. |
| Function | Anti-proliferative protein.the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors. Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth. |
| Protein Name | Protein Btg2Btg Family Member 2Ngf-Inducible Anti-Proliferative Protein Pc3 |
| Database Links | Reactome: R-HSA-6804115 |
| Alternative Antibody Names | Anti-Protein Btg2 antibodyAnti-Btg Family Member 2 antibodyAnti-Ngf-Inducible Anti-Proliferative Protein Pc3 antibodyAnti-BTG2 antibodyAnti-PC3 antibody |
Information sourced from Uniprot.org