Anti-BROX antibody (STJA0008913)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human C1orf58
General Information
| Short Description | Rabbit polyclonal anti-BRO1 domain-containing protein BROX for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | BROX |
| Gene ID | 148362 |
| Uniprot ID | BROX_HUMAN |
| Immunogen | Synthesized peptide derived from human C1orf58 |
| Specificity | This antibody detects endogenous levels of C1orf58 at Human, Mouse, Rat |
Additional Info
| Function | Nuclear envelope-associated factor that is involved in the nuclear envelope ruptures during interphase (NERDI) repair, where it is locally recruited by CHMP5 and reduces cytoskeletal stress through its action on SYN2 to help reseal the ruptured membrane. |
| Protein Name | Bro1 Domain-Containing Protein BroxBro1 Domain- And Caax Motif-Containing Protein |
| Database Links | |
| Cellular Localisation | Nucleus MembraneLipid-AnchorDuring Nuclear Envelope RepairLocalizes At Rupture Sites Where It Is Recruited By The Chmp7/Escrt-Iii Axis |
| Alternative Antibody Names | Anti-Bro1 Domain-Containing Protein Brox antibodyAnti-Bro1 Domain- And Caax Motif-Containing Protein antibodyAnti-BROX antibodyAnti-BROFTI antibodyAnti-C1orf58 antibody |
Information sourced from Uniprot.org