• Western blot analysis of lysates from 293 cells, using BRMS1 Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of various cells using BRMS-1 Polyclonal Antibody

Anti-BRMS1 antibody (21-70 aa) (STJ91892)

SKU:
STJ91892

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Breast cancer metastasis-suppressor 1 (21-70 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:20000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: BRMS1
Gene ID: 25855
Uniprot ID: BRMS1_HUMAN
Immunogen Region: 21-70 aa
Specificity: BRMS-1 Polyclonal Antibody detects endogenous levels of BRMS-1 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human BRMS1 at the amino acid range 21-70
Post Translational Modifications Ubiquitinated by a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing SPOP, leading to proteasomal degradation.
Function Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma.
Protein Name Breast Cancer Metastasis-Suppressor 1
Database Links Reactome: R-HSA-3214815
Reactome: R-HSA-9679191
Cellular Localisation Nucleus
Cytoplasm
Predominantly Nuclear
Alternative Antibody Names Anti-Breast Cancer Metastasis-Suppressor 1 antibody
Anti-BRMS1 antibody

Information sourced from Uniprot.org

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