| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Breast cancer metastasis-suppressor 1 (197-246 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000ELISA 1:20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
BRMS1 |
| Gene ID: |
25855 |
| Uniprot ID: |
BRMS1_HUMAN |
| Immunogen Region: |
197-246 aa |
| Specificity: |
BRMS-1 Polyclonal Antibody detects endogenous levels of BRMS-1 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the C-terminal region of human BRMS1 at the amino acid range 197-246 |
| Post Translational Modifications | Ubiquitinated by a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing SPOP, leading to proteasomal degradation. |
| Function | Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma. |
| Protein Name | Breast Cancer Metastasis-Suppressor 1 |
| Database Links | Reactome: R-HSA-3214815Reactome: R-HSA-9679191 |
| Cellular Localisation | NucleusCytoplasmPredominantly Nuclear |
| Alternative Antibody Names | Anti-Breast Cancer Metastasis-Suppressor 1 antibodyAnti-BRMS1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
