| Post Translational Modifications | In response to oxidative stress, Cys-361 is reversibly oxidized to cysteine sulfenic acid. Oxidation of Cys-361 impairs formation of a ternary complex with TBP and DNA and down-regulates expression of target genes in response to oxidative stress. |
| Function | General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites. Contributes to the regulation of gene expression.functions as activator in the absence of oxidative stress. Down-regulates expression of target genes in response to oxidative stress. Overexpression protects cells against apoptosis in response to oxidative stress. |
| Protein Name | Transcription Factor Iiib 50 Kda SubunitTfiiib50Htfiiib50B-Related Factor 2Brf-2Hbrfu |
| Database Links | Reactome: R-HSA-749476Reactome: R-HSA-76071 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Factor Iiib 50 Kda Subunit antibodyAnti-Tfiiib50 antibodyAnti-Htfiiib50 antibodyAnti-B-Related Factor 2 antibodyAnti-Brf-2 antibodyAnti-Hbrfu antibodyAnti-BRF2 antibodyAnti-BRFU antibodyAnti-PRO1470 antibody |
Information sourced from Uniprot.org
