| Function | Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis. Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time. In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA. Also recognizes and binds a subset of butyrylated histones: able to bind histone H4 butyrylated at 'Lys-8' (H4K8ac), while it is not able to bind H4 butyrylated at 'Lys-5' (H4K5ac). Also acts as a component of the splicing machinery in pachytene spermatocytes and round spermatids and participates in 3'-UTR truncation of specific mRNAs in post-meiotic spermatids. Required for chromocenter organization, a structure comprised of peri-centromeric heterochromatin. |
| Protein Name | Bromodomain Testis-Specific ProteinCancer/Testis Antigen 9Ct9Ring3-Like Protein |
| Cellular Localisation | NucleusDetected On Chromatin |
| Alternative Antibody Names | Anti-Bromodomain Testis-Specific Protein antibodyAnti-Cancer/Testis Antigen 9 antibodyAnti-Ct9 antibodyAnti-Ring3-Like Protein antibodyAnti-BRDT antibody |
Information sourced from Uniprot.org
