| Post Translational Modifications | Ubiquitinated by NEDD4, NEDD4L and ITCH.mono- and polyubiquitinated forms are detected. |
| Function | Component of a multiprotein complex required for the assembly of the RNA endonuclease module of the integrator complex. Associates with INTS9 and INTS11 in the cytoplasm and blocks the active site of INTS11 to inhibit the endonuclease activity of INTS11 before formation of the full integrator complex. Following dissociation of WDR73 of the complex, BRAT1 facilitates the nuclear import of the INTS9-INTS11 heterodimer. In the nucleus, INTS4 is integrated to the INTS9-INTS11 heterodimer and BRAT1 is released from the mature RNA endonuclease module by inositol hexakisphosphate (InsP6). BRAT1 is also involved in DNA damage response.activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress. Plays a role in regulating mitochondrial function and cell proliferation. Required for protein stability of MTOR and MTOR-related proteins, and cell cycle progress by growth factors. |
| Protein Name | Integrator Complex Assembly Factor Brat1Brca1-Associated Atm Activator 1Brca1-Associated Protein Required For Atm Activation Protein 1 |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmPresent At Double Strand Breaks (Dsbs)Following Ionizing Radiation TreatmentThe Ubiquitinated Form Localizes In The Nucleus In A Ndfip1-Dependent Manner |
| Alternative Antibody Names | Anti-Integrator Complex Assembly Factor Brat1 antibodyAnti-Brca1-Associated Atm Activator 1 antibodyAnti-Brca1-Associated Protein Required For Atm Activation Protein 1 antibodyAnti-BRAT1 antibodyAnti-BAAT1 antibodyAnti-C7orf27 antibody |
Information sourced from Uniprot.org
