Anti-BPTF antibody [2F10] (STJ97882)

Anti-BPTF antibody [2F10] (STJ97882)

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STJ97882
£149.00 - £360.00
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Short Description :Mouse monoclonal anti-Nucleosome-remodeling factor subunit BPTF for use in WB and ELISA in Human samples. Datasheet included with dilution recommendations, and related reagents.
Applications:WB/ELISA
Host:Mouse
Reactivity:Human
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Clone ID :2F10
Isotype:IgG2b
Conjugation:Unconjugated
Purification:Affinity purification
Dilution Range:WB 1:500-1:2000
ELISA 1:10000
Formulation:Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol.
Storage Instruction:Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol:BPTF
Gene ID:2186
Uniprot ID:BPTF_HUMAN
Immunogen:Purified recombinant fragment of human BPTF expressed in E. Coli.
Specificity:BPTF Monoclonal Antibody detects endogenous levels of BPTF protein.
Post Translational Modifications Phosphorylation enhances DNA-binding. Highly susceptible to proteolysis.
Function Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex. Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development. Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes. Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent. May also regulate transcription through direct binding to DNA or transcription factors.
Protein Name Nucleosome-Remodeling Factor Subunit Bptf
Bromodomain And Phd Finger-Containing Transcription Factor
Fetal Alz-50 Clone 1 Protein
Fetal Alzheimer Antigen
Database Links
Cellular Localisation Cytoplasm
Nucleus
Localizes To Sites Of Dna Damage
In Brains Of Alzheimer Disease Patients
Present In A Subset Of Amyloid-Containing Plaques
Alternative Antibody Names Anti-Nucleosome-Remodeling Factor Subunit Bptf antibody
Anti-Bromodomain And Phd Finger-Containing Transcription Factor antibody
Anti-Fetal Alz-50 Clone 1 Protein antibody
Anti-Fetal Alzheimer Antigen antibody
Anti-BPTF antibody
Anti-FAC1 antibody
Anti-FALZ antibody

Information sourced from Uniprot.org

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