| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-BPI (248-487) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
BPI |
| Gene ID: |
671 |
| Uniprot ID: |
BPI_HUMAN |
| Immunogen Region: |
248-487 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 248-487 of human BPI (NP_001716.2). |
| Immunogen Sequence: |
AETLDVQMKGEFYSENHHNP PPFAPPVMEFPAAHDRMVYL GLSDYFFNTAGLVYQEAGVL KMTLRDDMIPKESKFRLTTK FFGTFLPEVAKKFPNMKIQI HVSASTPPHLSVQPTGLTFY PAVDVQAFAVLPNSSLASLF LIGMHTTGSMEVSAESNRLV GELKLDRLLLELKHSNIGPF PVELLQDIMNYIVPILVLPR VNEKLQKGFPLPTPARVQLY NVVLQPHQNFLLFGADVVY |
| Tissue Specificity | Restricted to cells of the myeloid series. |
| Function | The cytotoxic action of BPI is limited to many species of Gram-negative bacteria.this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. |
| Protein Name | Bactericidal Permeability-Increasing ProteinBpiCap 57 |
| Database Links | Reactome: R-HSA-166016Reactome: R-HSA-6798695Reactome: R-HSA-6803157 |
| Cellular Localisation | SecretedCytoplasmic Granule MembraneMembrane-Associated In Polymorphonuclear Leukocytes (Pmn) Granules |
| Alternative Antibody Names | Anti-Bactericidal Permeability-Increasing Protein antibodyAnti-Bpi antibodyAnti-Cap 57 antibodyAnti-BPI antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
