| Host: |
Mouse |
| Applications: |
IHC-P |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-BOB1 (148-255aa) is suitable for use in Immunohistochemistry research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
ZM74 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG2b/Kappa |
| Formulation: |
Tris-HCI buffer containing stabilizing protein (BSA) and <0.1% ProClin |
| Purification: |
Affinity purified |
| Dilution Range: |
1:100‐200 |
| Storage Instruction: |
Store at 2‐8°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate lab‐standardized diluent. Stability after dilution: 7 days at 24°C, 3 months at 2‐8°C, 6months at ‐20°C. |
| Gene Symbol: |
POU2AF1 |
| Gene ID: |
5450 |
| Uniprot ID: |
OBF1_HUMAN |
| Immunogen Region: |
148-255aa |
| Specificity: |
Positive control: Tonsil |
| Immunogen: |
Recombinant human BOB1 (POU2AF1) protein fragment (around aa 148-255) |
| Tissue Specificity | B-cell specific. Detected in mainly in spleen, but also in thymus, periphral blood leukocyte and small intestine. |
| Post Translational Modifications | Ubiquitinated.mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation. |
| Function | Transcriptional coactivator that specifically associates with either POU2F1/OCT1 or POU2F2/OCT2. It boosts the POU2F1/OCT1 mediated promoter activity and to a lesser extent, that of POU2F2/OCT2. It recognizes the POU domains of POU2F1/OCT1 and POU2F2/OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers. Regulates IL6 expression in B cells as POU2F2/OCT2 coactivator. |
| Protein Name | Pou Domain Class 2-Associating Factor 1B-Cell-Specific Coactivator Obf-1Bob-1Oca-BOct-Binding Factor 1 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Pou Domain Class 2-Associating Factor 1 antibodyAnti-B-Cell-Specific Coactivator Obf-1 antibodyAnti-Bob-1 antibodyAnti-Oca-B antibodyAnti-Oct-Binding Factor 1 antibodyAnti-POU2AF1 antibodyAnti-BOB1 antibodyAnti-OBF1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
