| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
BNIP3L |
| Gene ID: |
665 |
| Uniprot ID: |
BNI3L_HUMAN |
| Specificity: |
BNI3L Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from part of the human protein |
| Function | Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor. |
| Protein Name | Bcl2/Adenovirus E1b 19 Kda Protein-Interacting Protein 3-LikeAdenovirus E1b19k-Binding Protein B5Bcl2/Adenovirus E1b 19 Kda Protein-Interacting Protein 3aNip3-Like Protein XNip3l |
| Database Links | Reactome: R-HSA-6803204 |
| Cellular Localisation | Nucleus EnvelopeEndoplasmic ReticulumMitochondrion Outer MembraneMembraneSingle-Pass Membrane ProteinColocalizes With Spata18 At The Mitochondrion Outer Membrane |
| Alternative Antibody Names | Anti-Bcl2/Adenovirus E1b 19 Kda Protein-Interacting Protein 3-Like antibodyAnti-Adenovirus E1b19k-Binding Protein B5 antibodyAnti-Bcl2/Adenovirus E1b 19 Kda Protein-Interacting Protein 3a antibodyAnti-Nip3-Like Protein X antibodyAnti-Nip3l antibodyAnti-BNIP3L antibodyAnti-BNIP3A antibodyAnti-BNIP3H antibodyAnti-NIX antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
