| Post Translational Modifications | Undergoes progressive proteolysis to an 11 kDa C-terminal fragment, which is blocked by the proteasome inhibitor lactacystin. |
| Function | Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor. |
| Protein Name | Bcl2/Adenovirus E1b 19 Kda Protein-Interacting Protein 3-LikeAdenovirus E1b19k-Binding Protein B5Bcl2/Adenovirus E1b 19 Kda Protein-Interacting Protein 3aNip3-Like Protein XNip3l |
| Database Links | Reactome: R-HSA-6803204 |
| Cellular Localisation | Nucleus EnvelopeEndoplasmic ReticulumMitochondrion Outer MembraneMembraneSingle-Pass Membrane ProteinColocalizes With Spata18 At The Mitochondrion Outer Membrane |
| Alternative Antibody Names | Anti-Bcl2/Adenovirus E1b 19 Kda Protein-Interacting Protein 3-Like antibodyAnti-Adenovirus E1b19k-Binding Protein B5 antibodyAnti-Bcl2/Adenovirus E1b 19 Kda Protein-Interacting Protein 3a antibodyAnti-Nip3-Like Protein X antibodyAnti-Nip3l antibodyAnti-BNIP3L antibodyAnti-BNIP3A antibodyAnti-BNIP3H antibodyAnti-NIX antibody |
Information sourced from Uniprot.org
