| Function | Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway. |
| Protein Name | Bcl2/Adenovirus E1b 19 Kda Protein-Interacting Protein 3 |
| Database Links | |
| Cellular Localisation | MitochondrionMitochondrion Outer MembraneSingle-Pass Membrane ProteinCoexpression With The Eib 19-Kda Protein Results In A Shift In Nip3 Localization Pattern To The Nuclear EnvelopeColocalizes With Acaa2 In The MitochondriaColocalizes With Spata18 At The Mitochondrion Outer Membrane |
| Alternative Antibody Names | Anti-Bcl2/Adenovirus E1b 19 Kda Protein-Interacting Protein 3 antibodyAnti-BNIP3 antibodyAnti-NIP3 antibody |
Information sourced from Uniprot.org
