Anti-BNI3L antibody [PT0956R] (STJA0039770)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgGk
General Information
| Short Description | Rabbit monoclonal anti-Bcl2/Adenovirus E1b 19 Kda Protein-Interacting Protein 3-Like for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | PT0956R |
| Isotype | IgGk |
| Conjugation | Unconjugated |
| Purification | Protein A |
| Dilution Range | IHC 1:200-1:1000WB 1:500-1:2000IF 1:200-1:1000ELISA 1:5000-1:20000 |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | BNIP3L |
| Gene ID | 665 |
| Uniprot ID | BNI3L_HUMAN |
| Specificity | Endogenous |
Additional Info
| Function | Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor. |
| Protein Name | Bcl2/Adenovirus E1b 19 Kda Protein-Interacting Protein 3-LikeAdenovirus E1b19k-Binding Protein B5Bcl2/Adenovirus E1b 19 Kda Protein-Interacting Protein 3aNip3-Like Protein XNip3l |
| Database Links | Reactome: R-HSA-6803204 |
| Cellular Localisation | Nucleus EnvelopeEndoplasmic ReticulumMitochondrion Outer MembraneMembraneSingle-Pass Membrane ProteinColocalizes With Spata18 At The Mitochondrion Outer Membrane |
| Alternative Antibody Names | Anti-Bcl2/Adenovirus E1b 19 Kda Protein-Interacting Protein 3-Like antibodyAnti-Adenovirus E1b19k-Binding Protein B5 antibodyAnti-Bcl2/Adenovirus E1b 19 Kda Protein-Interacting Protein 3a antibodyAnti-Nip3-Like Protein X antibodyAnti-Nip3l antibodyAnti-BNIP3L antibodyAnti-BNIP3A antibodyAnti-BNIP3H antibodyAnti-NIX antibody |
Information sourced from Uniprot.org