Anti-BMP6 antibody (375-513) (STJ118094)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal BMP6 (375-513) antibody for use in IF, ICC and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | IF/ICC:1:100-1:500ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | BMP6 |
| Gene ID | 654 |
| Uniprot ID | BMP6_HUMAN |
| Immunogen Region | 375-513 |
| Immunogen Sequence | SASSRRRQQSRNRSTQSQDV ARVSSASDYNSSELKTACRK HELYVSFQDLGWQDWIIAPK GYAANYCDGECSFPLNAHMN ATNHAIVQTLVHLMNPEYVP KPCCAPTKLNAISVLYFDDN SNVILKKYRNMVVRACGCH |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 375-513 of human BMP6 (NP_001709.1). |
Additional Info
| Post Translational Modifications | Glycosylated at Asn-454. Glycosylation is crucial for recognition by the activin receptor type I/ACVR1. |
| Function | Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes including cartilage and bone formation. Also plays an important role in the regulation of HAMP/hepcidin expression and iron metabolism by acting as a ligand for hemojuvelin/HJV. Also acts to promote expression of HAMP, potentially via the interaction with its receptor BMPR1A/ALK3. Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2B. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target. Can also signal through non-canonical pathway such as TAZ-Hippo signaling cascade to modulate VEGF signaling by regulating VEGFR2 expression. |
| Protein Name | Bone Morphogenetic Protein 6Bmp-6Vg-1-Related ProteinVg-1-RVgr-1 |
| Database Links | |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Bone Morphogenetic Protein 6 antibodyAnti-Bmp-6 antibodyAnti-Vg-1-Related Protein antibodyAnti-Vg-1-R antibodyAnti-Vgr-1 antibodyAnti-BMP6 antibodyAnti-VGR antibody |
Information sourced from Uniprot.org