| Host: |
Rabbit |
| Applications: |
IF |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-BMP6 (375-513) is suitable for use in Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
BMP6 |
| Gene ID: |
654 |
| Uniprot ID: |
BMP6_HUMAN |
| Immunogen Region: |
375-513 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 375-513 of human BMP6 (NP_001709.1). |
| Immunogen Sequence: |
SASSRRRQQSRNRSTQSQDV ARVSSASDYNSSELKTACRK HELYVSFQDLGWQDWIIAPK GYAANYCDGECSFPLNAHMN ATNHAIVQTLVHLMNPEYVP KPCCAPTKLNAISVLYFDDN SNVILKKYRNMVVRACGCH |
| Post Translational Modifications | Glycosylated at Asn-454. Glycosylation is crucial for recognition by the activin receptor type I/ACVR1. |
| Function | Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes including cartilage and bone formation. Also plays an important role in the regulation of HAMP/hepcidin expression and iron metabolism by acting as a ligand for hemojuvelin/HJV. Also acts to promote expression of HAMP, potentially via the interaction with its receptor BMPR1A/ALK3. Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2B. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target. Can also signal through non-canonical pathway such as TAZ-Hippo signaling cascade to modulate VEGF signaling by regulating VEGFR2 expression. |
| Protein Name | Bone Morphogenetic Protein 6Bmp-6Vg-1-Related ProteinVg-1-RVgr-1 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Bone Morphogenetic Protein 6 antibodyAnti-Bmp-6 antibodyAnti-Vg-1-Related Protein antibodyAnti-Vg-1-R antibodyAnti-Vgr-1 antibodyAnti-BMP6 antibodyAnti-VGR antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
