| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S4160RM |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | BMP4 |
| Gene ID: | 652 |
| Uniprot ID: | BMP4_HUMAN |
| Immunogen Region: | 250-350 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 250-350 of human BMP4 (NP_001193.2). |
| Immunogen Sequence: | QHVRISRSLPQGSGNWAQLR PLLVTFGHDGRGHALTRRRR AKRSPKHHSQRARKKNKNCR RHSLYVDFSDVGWNDWIVAP PGYQAFYCHGDCPFPLADHL N |
| Tissue Specificity | Expressed in the lung and lower levels seen in the kidney. Present also in normal and neoplastic prostate tissues, and prostate cancer cell lines. |
| Function | Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including neurogenesis, vascular development, angiogenesis and osteogenesis. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Positively regulates the expression of odontogenic development regulator MSX1 via inducing the IPO7-mediated import of SMAD1 to the nucleus. Required for MSX1-mediated mesenchymal molar tooth bud development beyond the bud stage, via promoting Wnt signaling. Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling. Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway. Can also signal through non-canonical BMP pathways such as ERK/MAP kinase, PI3K/Akt, or SRC cascades. For example, induces SRC phosphorylation which, in turn, activates VEGFR2, leading to an angiogenic response. |
| Protein Name | Bone Morphogenetic Protein 4 Bmp-4 Bone Morphogenetic Protein 2b Bmp-2b |
| Database Links | Reactome: R-HSA-2129379 Reactome: R-HSA-381426 Reactome: R-HSA-8957275 Reactome: R-HSA-9754189 Reactome: R-HSA-9758920 Reactome: R-HSA-9761174 Reactome: R-HSA-9793380 Reactome: R-HSA-9827857 Reactome: R-HSA-9830364 Reactome: R-HSA-9830674 Reactome: R-HSA-9834899 |
| Cellular Localisation | Secreted Extracellular Space Extracellular Matrix |
| Alternative Antibody Names | Anti-Bone Morphogenetic Protein 4 antibody Anti-Bmp-4 antibody Anti-Bone Morphogenetic Protein 2b antibody Anti-Bmp-2b antibody Anti-BMP4 antibody Anti-BMP2B antibody Anti-DVR4 antibody |
Information sourced from Uniprot.org