• Immunohistochemistry of mouse tissue with Anti-BMP2 primary antibody (STJ500263) at 1:50 dilution in Buffer. Section was treated with DAB and Haematoxylin stain. Magnification is at 5X.

Anti-BMP2 antibody (45-60) (STJ500263)

SKU:
STJ500263-100

£481.50
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Host: Rabbit
Applications: CM/ELISA/ICC/IF/IHC/IP/WB
Reactivity: Human/Monkey/Mouse/Pig
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-BMP2 (45-60) is suitable for use in Confocal Microscopy, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.73 µg/µl
Dilution Range: WB: 1:500-1:1000
DB: 1:2, 000
ELISA: 1:2, 000
IP: 1:200
IHC: 1:200-1:500
ICC: 1:200
IF: 1:200
CFM: 1:200
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Bmp2
Gene ID: 12156
Uniprot ID: BMP2_MOUSE
Immunogen Region: 45-60
Immunogen: Synthetic peptide corresponding to Mouse BMP2 amino acid region 45-60 conjugated to Keyhole Limpet Haemocyanin (KLH).
Function Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cardiogenesis, neurogenesis, and osteogenesis. Induces cartilage and bone formation. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Also acts to promote expression of HAMP, via the interaction with its receptor BMPR1A/ALK3. Can also signal through non-canonical pathways such as ERK/MAP kinase signaling cascade that regulates osteoblast differentiation. Also stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A-ATF4 pathway by stimulating EIF2A phosphorylation which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling.
Protein Name Bone Morphogenetic Protein 2
Bmp-2
Bone Morphogenetic Protein 2a
Bmp-2a
Database Links Reactome: R-MMU-201451
Reactome: -MMU-2129379
Cellular Localisation Secreted
Alternative Antibody Names Anti-Bone Morphogenetic Protein 2 antibody
Anti-Bmp-2 antibody
Anti-Bone Morphogenetic Protein 2a antibody
Anti-Bmp-2a antibody
Anti-Bmp2 antibody
Anti-Bmp-2 antibody

Information sourced from Uniprot.org

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