Anti-BIRC6 antibody (STJA0004819)

SKU:
STJA0004819

£132.50 - £370.50
Current Stock:
Host: Rabbit
Applications: IHC/ELISA
Reactivity: Human/Mouse
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Baculoviral Iap Repeat-Containing Protein 6 is suitable for use in Immunohistochemistry and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification: Affinity purification
Concentration: 0.3 mg/mL
Dilution Range: IHC 1:50-1:200
Storage Instruction: Store at-20°C for long term, and avoid freeze-thaw cycles.
Gene Symbol: BIRC6
Gene ID: 57448
Uniprot ID: BIRC6_HUMAN
Immunogen: Synthetic peptide of human BIRC6
Tissue Specificity Expressed in brain cancer cells.
Post Translational Modifications Ubiquitinated. Ubiquitination is mediated by the RNF41 E3 ligase and leads to proteasomal degradation, impairing inhibition of apoptosis. Deubiquitinated by USP8/UBPY.
Function Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its targets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification.
Protein Name Baculoviral Iap Repeat-Containing Protein 6
Bir Repeat-Containing Ubiquitin-Conjugating Enzyme
Bruce
Ring-Type E3 Ubiquitin Transferase Birc6
Ubiquitin-Conjugating Bir Domain Enzyme Apollon
Apollon
Database Links Reactome: R-HSA-9700645
Reactome: R-HSA-9725370
Cellular Localisation Golgi Apparatus
Trans-Golgi Network Membrane
Endosome
Cytoplasm
Cytoskeleton
Spindle Pole
Microtubule Organizing Center
Centrosome
Midbody
Midbody Ring
Exhibits Cell Cycle-Dependent Localization
Concentrates In A Pericentriolar Compartment In Interphase
Moves Partially To Spindle Poles In Metaphase
And Finally Localizes To The Spindle Midzone And The Midbody In Telophase And During Cytokinesis
On The Midbody
Localizes To The Midbody Ring
Also Called Flemming Body
In Interphase Cells
Localizes To The Trans-Golgi Network Membrane And Endosomes
During Cytokinesis
A Fraction Moves To The Midzone Where It Specifically Arrives At The Midbody Ring
After Abscission Completion
Travels With The Midbody Remnant Into One Daughter Cell
And Remains Bound To It Until A New Midbody Ring Is Formed During The Next Cell Division
Alternative Antibody Names Anti-Baculoviral Iap Repeat-Containing Protein 6 antibody
Anti-Bir Repeat-Containing Ubiquitin-Conjugating Enzyme antibody
Anti-Bruce antibody
Anti-Ring-Type E3 Ubiquitin Transferase Birc6 antibody
Anti-Ubiquitin-Conjugating Bir Domain Enzyme Apollon antibody
Anti-Apollon antibody
Anti-BIRC6 antibody
Anti-KIAA1289 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance