| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Bridging integrator 2 (260-340 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
BIN2 |
| Gene ID: |
51411 |
| Uniprot ID: |
BIN2_HUMAN |
| Immunogen Region: |
260-340 aa |
| Specificity: |
BIN2 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from the human protein at the amino acid range 260-340 |
| Function | Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. |
| Protein Name | Bridging Integrator 2Breast Cancer-Associated Protein 1 |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-9673768 |
| Cellular Localisation | CytoplasmCell ProjectionPodosome MembranePeripheral Membrane ProteinCytoplasmic SideCell CortexPhagocytic CupAssociates With Membranes Enriched In PhosphoinositidesDetected In The Actin-Rich Cell Cortex At The Leading Edge Of Migrating CellsDetected At PodosomesAt An Actin-Rich Ring-Like Structure |
| Alternative Antibody Names | Anti-Bridging Integrator 2 antibodyAnti-Breast Cancer-Associated Protein 1 antibodyAnti-BIN2 antibodyAnti-BRAP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
