• Immunohistochemical analysis of paraffin-embedded mouse-muscle, antibody was diluted at 1:100
  • Immunohistochemical analysis of paraffin-embedded mouse-muscle, antibody was diluted at 1:100
  • Immunohistochemical analysis of paraffin-embedded human-pancreas, antibody was diluted at 1:100
  • Immunohistochemical analysis of paraffin-embedded human-pancreas, antibody was diluted at 1:100
  • Western blot analysis of mouse brain cells using Amphiphysin II Polyclonal Antibody.. Secondary antibody was diluted at 1:20000

Anti-BIN1 antibody (C-Term) (STJ96681)

SKU:
STJ96681

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Myc box-dependent-interacting protein 1 (C-Term) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC-P 1:100-1:300
ELISA 1:20000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: BIN1
Gene ID: 274
Uniprot ID: BIN1_HUMAN
Immunogen Region: C-Term
Specificity: Amphiphysin II Polyclonal Antibody detects endogenous levels of Amphiphysin II protein.
Immunogen: Synthesized peptide derived from the C-terminal region of human Amphiphysin II.
Post Translational Modifications Phosphorylated by protein kinase C.
Function Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling. Is a negative regulator of endocytosis. Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production. In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates. May be involved in the regulation of MYC activity and the control cell proliferation. Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro.
Protein Name Myc Box-Dependent-Interacting Protein 1
Amphiphysin Ii
Amphiphysin-Like Protein
Box-Dependent Myc-Interacting Protein 1
Bridging Integrator 1
Database Links Reactome: R-HSA-8856828
Cellular Localisation Isoform Bin1: Nucleus
Cytoplasm
Endosome
Cell Membrane
Sarcolemma
T-Tubule
Isoform Iia: Cytoplasm
Alternative Antibody Names Anti-Myc Box-Dependent-Interacting Protein 1 antibody
Anti-Amphiphysin Ii antibody
Anti-Amphiphysin-Like Protein antibody
Anti-Box-Dependent Myc-Interacting Protein 1 antibody
Anti-Bridging Integrator 1 antibody
Anti-BIN1 antibody
Anti-AMPHL antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance